Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments
Summary: The deregulation of the actin cytoskeleton has been extensively studied in metastatic dissemination.However, the post-dissemination role of the actin cytoskeleton dysregulation is poorly understood.Here, we report that fascin, an actin-bundling protein, promotes lung cancer metastatic colonization by augmenting metabolic sten jacket m stre